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当前位置: 首页 > 产品中心 > Other_natural_proteins > Stemrd/DKK-1,人/500µg/DKK-500
商品详细Stemrd/DKK-1,人/500µg/DKK-500
Stemrd/DKK-1,人/500µg/DKK-500
Stemrd/DKK-1,人/500µg/DKK-500
商品编号: DKK-500
品牌: Stemrd
市场价: ¥62700.00
美元价: 31350.00
产地: 美国(厂家直采)
公司:
产品分类: 其它天然蛋白
公司分类: Other_natural_proteins
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
SourceHuman 293 CellsM.W.37-40 kDaCAS No.
Structural Info
FormulationLyophilized in sterile filtered solution of PBS.
ReconstitutionBefore reconstitution, a brief spin is recommend todrive down any material dislodged from the bottom of the tube. The lyophilized protein should bereconstituted in sterile H2O to a desired concentration.
StabilityThe lyophilized protein is stable for at least oneyear if stored at -80 °C. Reconstituted protein is stable for at least four weeks at 4 °C,but should be stored in aliquots at -80 °C for longer term. Avoidrepeated freeze and thaw.
PurityGreater than 90% as determined by SDS-PAGE analysis
Biological ActivityThe activity was determined by using a TCF reporter gene assay in cultured human cells.The IC50 ranges from 100 - 500 ng/ml in the inhibition of 100 ng/mL WNT-3a activity.Activity in other assays
Country of OriginUSA

DKK-1, Dickkopf-related protein-1, is a member of the DKKprotein family which includes DKK-1 through DDK-4. DKK was originally identified as ahead-forming molecule in Xenopus. Mechanisticstudies showed that DKK-1 inhibits the Wnt /β-catenin signaling pathway byforming inhibitory complexes with co-receptor LRP5/6. Inhibition of Wnt/β-catenin signaling isessential for posterior patterning and anterior development in vertebrates, supportedby the discovery that DKK-1 knock-out mice lack head formation. StemRDexpressed recombinant human DKK-1 in human 293 cells as a 37-40 kDaglycoprotein containing 235 amino-acid residues. It is purified by a series of chromatography including HPLC.

Product Sheet
品牌介绍
stemRD及其合作伙伴已经开发出一种高效的方法,可以在人细胞系中表达生物活性重组蛋白。由于这些细胞在无血清,无蛋白质和化学成分明确的培养基中生长,因此通过此过程制得的产品不含异种,并且具有人类特异性的转录后修饰,例如糖基化。使用该系统,我们已经能够生产出许多对干细胞的生长和分化至关重要的生物活性蛋白。