Stemrd/SB431542，ALK-4、-5、-7抑制剂/2 mg/SB-002
市场价：
¥980.00
美元价：
490.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Source | M.W. | 384.39 | CAS No. | 301836-41-9 | |
|---|---|---|---|---|---|
| Structural Info | 4-(5-BENZOL[1,3]DIOXOL-5-YL-4-PYRLDIN-2-YL-1H-IMIDAZOL-2-YL)-BENZAMIDE | ||||
| Formulation | Powder | ||||
| Reconstitution | Before reconstitution, werecommend a brief spin to drive down any material dislodged from the bottom ofthe tube. The compound is soluble inDMSO. | ||||
| Stability | The powder is stable for atleast 2 year if stored at -20°C. The dissolved compound is stable for at least 1 month at 4 °C, butshould be stored in aliquots at -20 °C for longer term. Protect from light. | ||||
| Purity | Greater than 98% as determined by LC/MS analysis.LC/MS and/or NMR data available upon request. | ||||
| Biological Activity | |||||
| Country of Origin | USA | ||||
A selectiveinhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinase ALK5 (IC50= 94 nM), and the related ALK4 and ALK7.Ref: Lapinget al. Inhibition of transforming growth factor (TGF)-β1-inducedextracellular matrix with a novel inhibitor of the TGF-β type I receptor kinaseactivity: SB-431542. Mol.Pharmacol. 62 58, 2002. Inmanet al. SB-431542 is a potent and specific inhibitor of transforminggrowth factor-β superfamily type I activin receptor-like kinase (ALK) receptorsALK4, ALK5, and ALK7. Mol.Pharmacol. 62 65, 2002.
Product Sheet
品牌介绍
stemRD及其合作伙伴已经开发出一种高效的方法，可以在人细胞系中表达生物活性重组蛋白。由于这些细胞在无血清，无蛋白质和化学成分明确的培养基中生长，因此通过此过程制得的产品不含异种，并且具有人类特异性的转录后修饰，例如糖基化。使用该系统，我们已经能够生产出许多对干细胞的生长和分化至关重要的生物活性蛋白。
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