Stemrd/PD0325901/50 mg/PD-050
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¥9180.00
美元价：
4590.00
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3392242852
电话号码：
4000-520-616
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info@ebiomall.com
商品介绍
| Source | M.W. | 482.19 | CAS No. | 391210-10-9 | |
|---|---|---|---|---|---|
| Structural Info | N-[(2R)-2,3-DIHYDROXYPROPOXY]-3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]-BENZAMIDE | ||||
| Formulation | Powder | ||||
| Reconstitution | Before reconstitution, we recommend a brief spin todrive down any material dislodged from the bottom of the tube. The compound is soluble in DMSO. | ||||
| Stability | The powder is stable for at least 2 year if stored at-20 °C. The dissolved compound isstable for at least 1 month at 4 °C, but should be stored in aliquots at-20 °C for longer term. Protectfrom light. | ||||
| Purity | Greater than 98% as determined by LC/MS analysis.LC/MS and/or NMR data available upon request. | ||||
| Biological Activity | |||||
| Country of Origin | USA | ||||
A selective inhibitor against purified MEK,exhibiting a Ki of 1 nM against activated MEK1 and MEK2. It has been shown that 1 µM PD0325901 combined with 3 µM CHIR99021 (2i)prevents cell differentiation and sustains self-renewal of murine embryonicstem cells.N-[(2R)-2,3-DIHYDROXYPROPOXY]-3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]-BENZAMIDERef: Barret, S.D., Bridges, A.J., Dudley,D.T., et al. Thediscovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901. Bioorg Med Chem Lett 186501-6504, 2008.Ying, Q., Wray, J., Nichols, J., et al. The ground state ofembryonic stem cell self-renewal. Nature 453 519-524, 2008.
品牌介绍
stemRD及其合作伙伴已经开发出一种高效的方法，可以在人细胞系中表达生物活性重组蛋白。由于这些细胞在无血清，无蛋白质和化学成分明确的培养基中生长，因此通过此过程制得的产品不含异种，并且具有人类特异性的转录后修饰，例如糖基化。使用该系统，我们已经能够生产出许多对干细胞的生长和分化至关重要的生物活性蛋白。
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