Stemrd/LGK974，WNT抑制剂/10 mg/L974-010
市场价：
¥13380.00
美元价：
6690.00
产品分类：
酶抑制剂
公司分类：
Enzyme_Inhibitors
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Source | M.W. | 396.4 | CAS No. | 1243244-14-5 | |
|---|---|---|---|---|---|
| Structural Info | |||||
| Formulation | Powder | ||||
| Reconstitution | Before reconstitution, werecommend a brief spin to drive down any material dislodged from the bottom ofthe tube. The compound is soluble inDMSO. | ||||
| Stability | The powder is stable for atleast 2 year if stored at -20 °C. The dissolved compound is stable for at least 1 month at 4 °C, butshould be stored in aliquots at -20 °C for longer term. Protect from light. | ||||
| Purity | Greater than 99% as determined by LC/MS analysis. | ||||
| Biological Activity | In a co-culture assay measuring the activation of the TCF reporter gene by Wnt3a-secreting cells, this compound gives IC50 of 0.2 to 0.6 nM. | ||||
| Country of Origin | USA | ||||
LGK974 isa potent and specific inhibitor of O-acyltransferase Porcupine (Porcn)that acylates Wnt proteins required for their biological activities. The structure of LGK974 was recentlypublished (Ref. 1). Not only morepotent than the IWP1,2,3,4 Porcn inhibitors (Ref. 2), LGK974 is also suitablefor in vivo studies and is currentlyin the Phase I clinical trials to treat cancers.Ref 1. Discovery of LGK974: Aselective Porcupine inhibitor targeting Wnt signaling in cancer. Shifeng Pan(Novartis), 2013 AACR Annual Meeting.Ref2. Chen B., et al. Smallmolecule-mediated disruption of Wnt-dependent signaling in tissue regenerationand cancer. Nat Chem Biol. 2009;5(2):100-7.
品牌介绍
stemRD及其合作伙伴已经开发出一种高效的方法，可以在人细胞系中表达生物活性重组蛋白。由于这些细胞在无血清，无蛋白质和化学成分明确的培养基中生长，因此通过此过程制得的产品不含异种，并且具有人类特异性的转录后修饰，例如糖基化。使用该系统，我们已经能够生产出许多对干细胞的生长和分化至关重要的生物活性蛋白。
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