Stemrd/GDC-0449，SMO拮抗剂/5 mg/G449-005
市场价：
¥1880.00
美元价：
940.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Source | M.W. | 421.3 | CAS No. | 879085-55-9 | |
|---|---|---|---|---|---|
| Structural Info | C19H14Cl2N2O3S | ||||
| Formulation | Powder | ||||
| Reconstitution | Before reconstitution, werecommend a brief spin to drive down any material dislodged from the bottom ofthe tube. The compound is soluble inDMSO. | ||||
| Stability | The powder is stable for at least 2 yearif stored at -20 °C. Thedissolved compound is stable for at least 1 month at 4 °C, but shouldbe stored in aliquots at -20 °C for longer term. Protect from light. | ||||
| Purity | Greater than 99% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request. | ||||
| Biological Activity | In a cell-based assay measuring the activation of the Gli-1 reporter gene, this compound gives IC50 of 5-20 nM. | ||||
| Country of Origin | USA | ||||
GDC-0449 (Vismodegib) ispotent antagonist of SMO (smoothened). This small molecule compound is a hedgehog pathway inhibitor by directlybinding to SMO. This molecule has beendeveloped by Genentech for clinical application against hedgehog-dependentcancers.Ref:Robarge KD, et al. Bioorg Med Chem Lett.Oct 1 2009 19: 5576-81; van Hoff DD, etal. N Engl J Med. Sep 17, 2009 361: 1164-72; Rudin CM et al. N Engl J Med. 2009 Sep 17; 361(12):1173-8.
Product Sheet
Okabe S, Tauchi T, Tanaka Y, et al., Effects ofthe hedgehog inhibitor GDC-0449, alone or in combination with dasatinib, onBCR-ABL-positive leukemia cells. Stem Cells Dev. 2012 Nov1;21(16):2939-48.http://www.ncbi.nlm.nih.gov/pubmed/22642671
品牌介绍
stemRD及其合作伙伴已经开发出一种高效的方法，可以在人细胞系中表达生物活性重组蛋白。由于这些细胞在无血清，无蛋白质和化学成分明确的培养基中生长，因此通过此过程制得的产品不含异种，并且具有人类特异性的转录后修饰，例如糖基化。使用该系统，我们已经能够生产出许多对干细胞的生长和分化至关重要的生物活性蛋白。
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